Manchester City beat League Cup holders Liverpool 3-2 in a cracking game on Thursday, taking the lead three times before holding on to reach the quarter-finals.
Aguero's absence means a likely start for Brazilian Gabriel Jesus in attack.
City having already bagged the title and Newcastle safe, there was nothing riding on the fixture but it served up some rich entertainment
Bayern Munich may be missing some of their biggest names when they travel to Porto for the first leg of their Champions League last eight on Wednesday but the Germans are confident they have enough firepower to defend their favourites tag.
Phil Foden kept Manchester City's Premier League title challenge on track with a superb second-half double as his side hit back to clinch a 3-1 home victory over Manchester United on Sunday.
Salah's sublime second-half strike leaves Liverpool on 67 points, three ahead of second-placed Arsenal and four ahead of City on a pivotal day in the title race.
Bayern Munich slumped to their first defeat for three months when the Bundesliga leaders suffered a shock 2-1 reverse at home to Mainz 05 on Wednesday.
Manchester City's Kevin de Bruyne sparked a late comeback 3-2 victory for his side at Newcastle United.
Manchester City moved 13 points clear at the top of the English Premier League table after a 2-1 win over West Ham United on Saturday - their 20th straight win in all competitions.
Guardiola expects this season's Premier League title race to be more open than last season's
Having left it late to earn a 3-2 win in the first leg, City took a while to hit their stride at The Etihad on Tuesday but when they did Guardiola's team produced a magnificent attacking display that will ring alarm bells around Europe.
Juergen Klopp's side will meet the winners of Sunday's other semi-final between Chelsea and Crystal Palace in the May 14th final
Manchester City survived a scare to beat FC Copenhagen 3-1 in the first leg of their Champions League last-16 tie at the Parken Stadium on Tuesday, with Phil Foden scoring late to ensure a two-goal cushion ahead of the second leg.
Messi has been linked with a move away from the Camp Nou at the end of the season after he caused a stir by criticising the club's sporting director Eric Abidal
Manchester City inched closer to their treble as they downed Manchester United in the FA Cup final on Saturday.
Ronaldo back for Man Utd but injured Shaw faces weeks out
European champions Bayern Munich have strengthened their midfield by agreeing to buy sought-after Spain Under-21 international Thiago Alcantara from Barcelona for a fee of 25 million euros.
The winner will be named on August 26, along with UEFA's women's player of the year and Champions League positional award winners, at the Champions League group stage draw in Istanbul.
After the reigning English Premier League champions suffered a shocking 0-1 defeat at home to Bournemouth on Saturday, will Jose Mourinho continue to lead the defending champions for the second half of the season? Here's a look the men who could take over at Stamford Bridge.
Goals from Rodri and Kevin De Bruyne secured a comfortable win at the Etihad
Spain's Nolito clueless about British referendum moniker
Kevin de Bruyne has been named the Premier League's Player of the Season for the 2021-22 campaign
Manchester City's Erling Haaland faces Borussia Dortmund and Barcelona's Robert Lewandowski meets Bayern Munich after the Champions League group-stage draw was made on Thursday.
IMAGES from the Premier League matches played across England, on Saturday.
Roger Federer has joined the list of sports stars helping out the needy during the coronavirus pandemic, with the former world number one and his wife donating one million Swiss Francs ($1.02 million) to vulnerable families in his native Switzerland. Barcelona forward Lionel Messi and Manchester City manager Pep Guardiola had each donated one million euros ($1.08 million) to help clinics and medical centres fight the outbreak.
Liverpool ripped apart Manchester City with three goals inside the opening 31 minutes as they won their Champions League quarter-final, first leg tie 3-0 on Wednesday.
An in-form Bayern Munich will be looking to notch up their fourth straight win in the Champions League group stage and seal a spot in the final 16 when the Bundesliga champions face Viktoria Plzen on Tuesday.
Rediff.com brings a preview of the main matches coming up this weekend in the English Premier League.
Kevin De Bruyne netted a stunning equaliser with a rasping low strike to give Manchester City a 1-1 draw against Real Madrid
Real Madrid's Karim Benzema, who won the 2022 Ballon d'Or award, is also in the shortlist.
City Football Group will be a 65 per cent majority stakeholder of the club, alongside existing shareholders, actor Ranbir Kapoor and Bimal Parekh, who will keep the remaining 35 per cent.
Manchester City struck an early blow for the forthcoming Premier League campaign as they beat Liverpool on penalties to win the Community Shield at Wembley on Sunday after an absorbing contest had finished 1-1.
Manchester City have one just victory from their last 10 games across all competitions.
ManchesterCity could be without playmaker David Silva for Saturday's home game against Bournemouth while midfielder Ilkay Guendogan may make his Premier League debut.
After bagging the League Cup, being locked in a titanic battle with Liverpool for the Premier League title and in the Champions League quarter-finals, Pep Guardiola's side remain on course for an unprecedented clean sweep.
Yaya Toure has been left out of Manchester City's Champions League squad by coach Pep Guardiola, further undermining the Ivorian's position at the club. Toure, a mainstay of the City midfield since joining from Guardiola's Barcelona in 2010, has failed to start any of the club's opening three Premier League matches. He has only played once this season, in the second leg of the Champions League playoff tie against Steaua Bucharest, when they already had a 5-0 lead from the first encounter.
IMAGES from the UEFA Champions League matches played on Tuesday.
Manchester City squandered a three-goal lead to draw 3-3 with Feyenoord in the Champions League on Tuesday.
English clubs took their spending on players for the season soaring past 1 billion pounds on Monday, but the biggest signing on transfer deadline day was that of a manager as Manchester City confirmed Pep Guardiola will take over this summer.
Bayern Munich midfielder Bastian Schweinsteiger is doubtful for their Super Cup game against Chelsea on Friday in Prague after straining his ankle in a 1-1 Bundesliga draw at Freiburg on Tuesday.
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